[Core 3 synthase is down-regulated in colon carcinoma and suppresses the cancer metastasis]. This message will disappear when all data is loaded. The enzyme forms a beta-D-GlcNAc-(1,3)-D-Gal glycosidic linkage, UDP-N-acetyl-D-glucosamine + phenyl 4-O-(6-deoxy-beta-D-galactopyranosyl)-beta-D-glucopyranoside, UDP + GlcNAcbeta(1-3)(6deoxy)Galbeta(1-4)Glcbeta-phenyl, 289% of the activity with phenyl beta-lactoside. ; Holgersson, J. O-glycan repertoires on a mucin-type reporter protein expressed in CHO cell pools transiently transfected with O-glycan core enzyme cDNAs, Use of this online version of BRENDA is free under the CC BY 4.0 license. ; Grencis, R.K.; Philpott, D.J. the enzyme is a Zn-metallophosphatase containing an essential zinc ion in the active site The enzyme forms a beta-D-GlcNAc-(1,3)-D-Gal glycosidic linkage, UDP-N-acetyl-D-glucosamine + phenyl 4-O-(3-deoxy-beta-D-xylo-hexopyranosyl)-beta-D-glucopyranoside, 3% of the activity with phenyl beta-lactoside. To select more than one organism, hold the CTRL key and click the items in the list. Regulation of O-glycan biosynthesis, overview, disruption of the C3GnT gene reduces levels of colon-specific Muc2 protein. BRENDA - The Comprehensive Enzyme Information System the joker ? CHO cells are transiently co-transfected with plasmids encoding extended C1 beta3GnT3, C2 beta6GnT1, or C3 beta3GnT6 with or without ST6Gal I or CHST4, respectively, and resulting O-glycan and core chain spectrum, overview, the enzyme would be a useful marker for distinguishing between benign adenomas and premalignant lesions, High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis, Homo sapiens, no activity in Canis familiaris, Ovis aries, Platyrrhini, Rattus norvegicus, Sus scrofa. The enzyme forms a beta-D-GlcNAc-(1,3)-D-Gal glycosidic linkage, UDP-N-acetyl-D-glucosamine + phenyl beta-lactoside, UDP + GlcNAcbeta(1-3)Galbeta(1-4)Glc-phenyl, the enzyme forms a beta-D-GlcNAc-(1,3)-D-Gal glycosidic linkage, R: polypeptide derived from mucin, involved in mucin oligosaccharide biosynthesis, important role in synthesis of mucin-type O-glycans in digestive organs, substrate specificity is significantly influenced by the structure of the aglycon group, activity is restricted to mucins from specific tissues, e.g. Send us your paper, and we will do … The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. Glycosylation-related genes in CHO-K1 cells are present, but strictly suppressed and regulated. Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity. Role of Nod proteins in regulation of intestinal goblet cell response in naive mice and mice infected with the enteric parasite Trichuris muris, overview. ; Shajib, M.S. Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. means exactly one of any character if you do not know the exact spelling of a word. BRENDA contains all enzymes classified according to the system of the EC numbers, which was implemented in 1955 by the International Commission of Enzymes [now the International Union of Biochemistry and Molecular Biology, IUBMB (2)]. stomach, small intestine, and colon, N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosamine is bound to the glycoprotein via serine or threonine residues, no activity towards alpha-GalNAc residues of blood group A and the core 6 substrates, and beta-GalNAc residues of gangliosides, asialo-, lyso- and GalNAc-beta-1,4-(NeuAc-alpha-2,3-)Gal-beta-1,4-Glc-beta-1-1ceramide, i.e. This message will disappear when the data is sorted. ; Xia, L.; Schertzer, J.D. We're sorry, but BRENDA doesn't work properly without JavaScript. EXTERNAL LINKS (specific for EC-Number 2.4.1.147).
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