He was brother to architect James Playfair and engineer William Playfair, as well as uncle of the architect William Henry Playfair. Myelin and myelin-producing oligodendrocytes are damaged in many human diseases including Multiple Sclerosis (MS) and Motor Neurone Disease. granted degree awarding powers. The group of Prof. David Lyons study myelinated axons. “Recognised body” which has been 21 likes. Unless explicitly stated otherwise, all material is copyright © The University of Edinburgh 2020. Our lab uses zebrafish for two principle reasons: their amenability for live cell imaging and high-resolution cellular analyses, and their ability to be used to carry out large-scale genetic and chemical screens. We use zebrafish to dissect the molecular and cellular basis of nervous system development. He then undertook postdoctoral work at Stanford University in 2004 and joined the University of Edinburgh in 2009. https://www.euanmacdonaldcentre.org/people/prof-david-lyons
He founded Farmer's Magazine (1800), took over the Scots Magazine (1801), founded the Edinburgh Review (1802) and obtained the publishing rights to the Encyclopædia Britannica (1812). Nov 15: David Lyons (Centre for Neuroregeneration) has been appointed to a Personal Chair with effect from 1st November 2015. Please also visit our home at the Centre for Discovery Brain Sciences, University of Edinburgh, and on the Zebrafish Information Network (ZFIN). We use zebrafish to dissect the molecular and cellular basis of nervous system development. processes. View David Lyon’s profile on LinkedIn, the world's largest professional community. David has 1 job listed on their profile. David Lyons received his BSc (Neuroscience, 1999) and PhD (Developmental Biology, 2003) from University College London. Myelin is made by specialized cells called oligodendrocytes and is a layer of insulation that is wrapped around our nerve cables (axons). These facts coupled with the relative simplicity of the early nervous system and the availability of transgenic lines that drive fluorescent reporters in a variety of cell types, make the zebrafish ideal for live in vivo imaging of entire developmental processes. The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336, VAT Registration Number GB 592 9507 00. Willingness to discuss research projects with undergraduate and postgraduate students: YES - please click here. See the complete profile on LinkedIn and discover David… We are currently also embarking on a new forward genetic (gene discovery screen), using a transgenic reporter of myelination, to identify the molecular basis of central nervous system (CNS) myelination by oligodendrocytes in vivo, a process about which surprising little is known. Our current focus is on elucidating mechanisms that orchestrate the formation of myelinated axons. David Lyons' Lab, Edinburgh, United Kingdom. Myelin allows the rapid propagation of information throughout our nervous system, and it is also essential for axon health. The Lyons group use zebrafish in their research to find strategies to understand how myelin is made and how it can be repaired in disease. Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M. Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, Brückner BR, Alexopoulos I, Czopka T, Jung SY, Rhee JS, Janshoff A, Witke W, Schaap IAT, Mensch S, Baraban M, Czopka T, Ausborn J, El Manira A, and. In parallel we carrying out chemical compound based screens as an additional approach to identify the molecular basis of CNS myelination, and as part of collaborative drug discovery projects (see Collaborators below).
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